ABSTRACT
Background: Previous study showed leprosy patients have low zinc status. Yet the status of zinc in close-contact, which indicated by IgM anti-PGL1 level, have not determined. The aim of the study was to determine the association of zinc plasma and IgM anti-PGL-1 levels among close contact of leprosy patients in Indonesia. Methods: This was an observational study. Subjects were 186 close-contact leprosy patients. Measurement of zinc plasma status used atomic absorption spectrophotometer while examination of IgM anti-PGL1 level used ELISA (Polyclonal rabbit anti human IgM/HRP/(Dako®). Results: The average level of IgM anti-PGL1 and zinc plasma were 804 unit/mL (± 439.4) and 16.6 μmol/L (± 3.5) consecutively. There was significant correlation between zinc plasma and IgM anti-PGL1 (r = - 0.230; p = 0.002). Conclusion: There is a significant correlation between zinc plasma and IgM anti-PGL1 in close contact of leprosy
Subject(s)
LeprosyABSTRACT
Background: WHO classified the number of leprosy cases in Indonesia as number three in the world after India and Brazil. The number of new leprosy patients tends to increase since there is a possibility that seropositive leprosy is turning into manifest leprosy. The aim of this study was to analyze the influence of zinc supplementation on interleukin-2 (IL-2) level of seropositive contact of leprosy patients with marginal zinc deficiency. Methods: Twenty two subjects aged 20-40 years were recruited for this study. The zinc-supplemented group received 40 mg elemental Zn/d orally for 3 months. Seropositive leprosy was determined by examining IgM anti Phenolic Glycolipid–1 level and concentration of IL-2 in lymphocyte cell culture supernatant fluid were measured by Elisa method. Results: The IL-2 concentration in the subject in the zinc group was relatively not changed (p= 0.721), whereas that in placebo group tended to be significantly lower (p= 0.025) at the end of the study. Conclusion: There was a significant change of IL-2 level between both groups (p= 0.037).